The Significant Role of Women in Joseph Conrads Heart of...

In the 1900s novella Heart of Darkness by Joseph Conrad, the protagonist often encounters women at landmarks of his life. Charlie Marlow is a sailor and imperialist who sets out along the Congo River to â€Å"civilize† the â€Å"savages.† The novella begins with a crew on the Thames waiting for the tides to change. During their wait, a character named Marlow tells of his exploits on the African continent. In his recounted travels, Marlow meets other imperialists such as Mr. Kurtz, a man who is obsessed with the pursuit of ivory and riches. Like Mr. Kurtz, Marlow embarks across the African continent in hopes of earning both money and respect. One early critic of the novel, Edward Garnett, wrote in his review that â€Å"[Heart of Darkness] is simply a†¦show more content†¦Women are viewed by Marlow as ignorant little creatures above the press of imperialism—completely innocent, but entirely unaware. Africa is written â€Å"as setting and backdrop which eliminates the African as human factor. Africa as a metaphysical battlefield devoid of all recognizable humanity, into which the wandering European enters at his peril† (Achebe). Thus Conrad brings the savages of Africa and general women together. Marlow brings the two victims of imperialism together in one, brief observation of Mr. Kurtz’s foreign mistress. Conrad’s concise description of an Amazonian woman on page 56 is as follows: â€Å"†¦She was savage and superb, wild-eyed and magnificent; there was something ominous and stately in her deliberate progress†¦ â€Å"Her long shadow fell to the water’s edge. Her face had a tragic and fierce aspect of wild sorrow and of dumb pain mingled with the fear of some struggling, half-shaped resolve. She stood looking at us without a stir, and like the wilderness itself, with an air of brooding over an inscrutable purpose†¦Ã¢â‚¬  Women and the savages are brought together under one umbrella of mingled patronization and awe. In this respect, Marlow’s view of women is the perfect oxymoron (Nadelhaft). Marlow’s tone concerning women and the Amazon is reverent, but belittling. These two groups of people are sub-human to Marlow in that he considers them of a lesser intellect and lesser value.Show MoreRelatedGender Role In Joseph Conrad’s Heart of Darkness Essay1430 Words   |  6 PagesGender Role In Joseph Conrad’s Heart of Darkness For the most part people who read Heart of Darkness by Joseph Conrad may feel that the novella is strictly a story of exploration and racial discrimination. But to Johanna Smith who wrote â€Å"’Too Beautiful Altogether’: Ideologies of Gender and Empire in Heart of Darkness† it is much more than that. Johanna Smith along with Wallace Watson and Rita A. Bergenholtz agree that throughout Heart of Darkness there are tones of gender prejudice, but the wayRead MoreEssay on Hearts of Darkness: Post Colonialism850 Words   |  4 PagesWrite a critique of Joseph Conrads Heart of Darkness, based on your reading about post-colonialism and discussing Conrads view of African culture as other. What would someone from Africa think about this work? Heart of Darkness starts out in London and also ends there as well. Most of the story takes place in the Congo which is now known as the Republic of the Congo. Heart of Darkness was essentially a transitional novel between the nineteenth and twentieth centuries. During the nineteenthRead More Misleading Interpretations of Conrads Heart of Darkness Essays1186 Words   |  5 PagesMisleading Interpretations of Conrads Heart of Darkness Chinua Achebe, a well-known writer, once gave a lecture at the University of Massachusetts about Joseph Conrads Heart of Darkness, entitled An Image of Africa: Racism in Conrads Heart of Darkness. Throughout his essay, Achebe notes how Conrad used Africa as a background only, and how he set Africa up as a foil to Europe,(Achebe, p.251) while he also projects the image of Africa as the other world, the antithesis of Europe andRead MoreMarginalization: Heart of Darkness and God of Small Things1463 Words   |  6 Pagessince the half yearly. Issues of racism, women discrimination and the corruption of power used to be subtly touched upon or ignored. However they were also viewed differently depending on the era it was brought up in. Yet as time passed by, it seems these issues have become common discussion. This change of significance in how the audience responds and view texts that carry the notions of marginalization can be seen by Joseph Conrad’s ‘Heart of Darkness’ and Arundhati Roy’s ‘God of Small Things’Read MoreHeart Of Darkness Essay1426 Words   |  6 PagesJoseph Conrads novel Heart of Darkness uses character development and character analysis to really tell the story of European colonization. Within Conrads characters one can find both racist and colonialist views, and it is the opinion, and the interpretation of the reader which decides what Conrad is really trying to say in his work. Chinua Achebe, a well known writer, once gave a lecture at the University of Massachusetts about Joseph Conrads Heart of Darkness, entitled An image of Africa:Read More The Portrayal of Women in Joseph Conrads Heart of Darkness Essay1201 Words   |  5 PagesWomen have gained equality with men over the many centuries of the evolution of the modern western civilization. Hence, it cannot be overlooked that there still exist many literary examples of social disregard for woman potential. Joseph Conrads Heart of Darkness exemplifies the Western patriarchal gender roles in which women are given the inferior status.p Not only are women portrayed as being inferior to men, but Marlows (the protagonists) seldom mentioning of them in his Congo adventureRead MoreAnalysis Of Joseph Conrad s Heart Of Darkness892 Words   |  4 Pages In Joseph Conrad’s Heart of Darkness, women characters hold minor, but significant roles. Female appearances, although few, are powerful and impressionable. Their presence aid Marlow gain insight and knowledge throughout his journey. The few female characters that are mentioned in this novella are depicted as voiceless and insignificant. Their presence is held as insignificant, so much that women were never named and only referenced to by a title, thus not given an identity. Although voicelessRead MoreEssay Symbolism In Heart Of Darkness1077 Words   |  5 Pagesencountered in Joseph Conrad’s Heart of Darkness lies a tale saturated with subtle, yet, significant imagery that brings forth the true meaning of the novella. Throughout Heart of Darkness Conrad uses a plethora of simple colors, objects, and places to convey multifaceted images and ideas. His fine execution of the tools of the English language allows him to quickly lure the reader aboard the Nellie and not release him until the horror is over. Although the interpretation of symbols in the Heart of DarknessRead MoreThe Heart Of Darkness : Small Roles, Big Impact998 Words   |  4 PagesWomen in Heart of Darkness: Small Roles, Big Impact In Joseph Conrad’s Heart of Darkness, women characters hold minor, but significant roles. Female appearances, although few, are powerful and impressionable. Their roles, although conflicting and serving different purposes, influence Marlow’s journey significantly. The few female characters that are mentioned in this novella are depicted as voiceless and insignificant. Their presence is held as insignificant, so much that women were never namedRead MoreSimilarity in Joseph Conrads Heart of Darkness and Lord Jim3156 Words   |  13 PagesSimilarity in Joseph Conrad’s Heart of Darkness and Lord Jim Many times, after a successful novel, an author will publish another story very similar to the praised one. Joseph Conrad followed in suit with the previous statement. After the publication of Heart of Darkness in 1899, Lord Jim was released in 1900. However, according to majority of his critics, Conrad’s Lord Jim arguably outdoes Heart of Darkness to be named his best work. Few realize, though, that Lord Jim was actually started before

Political Politics Of The United States Essay - 1199 Words

A diverse society requires a pluralistic political structure in order to enfranchise citizens and allow the broadest scope of opinions to be heard. The United States has a rich history filled with specific examples of how an individual’s voice carries enough weight to make both a difference. However, a person’s ability to make a political impact does not necessitate eloquence and or individual intrepidity. Rather, our Founding Fathers carefully crafted a democratic system in which the voices of every individual were given significance and influence through their right to vote in elections. Unfortunately, political elections are not as idealistic as our fore fathers may have intended. In recent years, political campaigns in the United States have become an increasingly distasteful process in recent years, specifically in regard to the way in which they are funded. Political campaigns are regularly fuel by greed, power and a shady procurement of financial support. This corruption promotes inequitable campaign procedures, and almost never results in a fair and unbiased candidate victory. In recognition of this exploitation of power, steps have been taken by federal and state legislatures to regulate rampant unethical funding in political elections. In response to these efforts, two distinct sides have emerged. Proponents of campaign finance limits argue that wealthy donors and corporations hold too much sway in elections and as a result, corrupt campaigns. Those favoring lessShow MoreRelatedPolitical Relations Between The United States And Politics1328 Words   |  6 Pa gesthus be affected by institutions in two different countries. In this essay I will talk about the political institution in both countries. I will start by explaining politics in the United States and lead into how politics in Mexico function. Afterwards, I will compare both political institutions and draw from my own experiences to explain any differences between the two. The United States political system functions under a system of checks and balances. Our government is divided up into three branches:Read MoreAmerican Politics Vs. The Netflix Series House Of Cards756 Words   |  4 PagesProvisional Title A Case Study on American politics portrayed in House of Cards and its correlation to the current political climate 1 Introduction The American Netflix series House of Cards is a political drama that follows Frank Underwood (Kevin Spacey) rising through the ranks from Democratic Majority Whip in the House of Representatives to Vice President and later President of the United States by achieving his political power through manipulation and ruthless pragmatism with the aid of hisRead MorePolitical Parties : Politics, And Religion1480 Words   |  6 Pagesheld interest in politics, and the issues that affect the way we govern. So I boiled that down to the entities that decide when and what we govern. Political Parties. After I had my subject I looked at the three things I believe political parties play a role in. The three areas of interest I chose were our political parties role in our history, economics, and religion, and what factors in those areas determine how political parties’ function. The first area I looked at was political parties role inRead MorePolitics Is All About Gaining And Maintaining Power1438 Words   |  6 PagesPolitics is all about gaining and maintaining power. Politics is the business of humans endeavoring to success over their own disarray, uncertainty, competitiveness, egotism, and betrayal; formulate all the comparisons you want, but a lot of politics is simply concrete and visible, instead of being realistic. Politician tries to obtain power for their self or for â€Å"people†. Once they obtain power they make sure to preserve it. Correspondingly countries also try obtaining power and maintain powerRead MoreVisual Arts : The Most Accessible Politically Charged Art Form For United States Citizens1642 Words   |  7 Pagesform for United States citizens. Visual arts are intended to occupy an individual’s senses more than other forms of art, thus they have the power to teach, inspire and shape the perceptions of individuals. Cinemas help to create a shared narrative experience amongst people from different cultural backgrounds, forcing audiences to collectively consider topics they may have never believed serious before. Fi lms have the capacity to stir an individual to action, transform their view on politics and affectRead MoreEssay about The Underrepresentation of Women in United States Politics1147 Words   |  5 PagesThe Underrepresentation of Women in United States Politics I. Introduction and Context Women are numerically underrepresented in United States politics. Though people may see famous faces of women in politics around them, a mere 17 percent of leaders of the Federal government in the United States are women. Not only, at the Federal level are women underrepresented, but also at the state and local levels. Only in six states are there female governors, and members of city hall are predominately maleRead MoreThe Health Of American Politics Essay1053 Words   |  5 PagesThe Health of American Politics/Democracy In this paper, I am going to write about two topics which they are the American politics and the American democracy. I am going to discuss one issue regarding each topic. In the topic of American politics, I will describe the negative impact of the Israeli lobby on the American Politic. After that, I will describe the negative impact of the electoral college system on the American democracy. The Israeli lobby and the electoral college system are affectingRead MoreMigration Problems for Puerto Ricans1681 Words   |  7 Pageshistorical repetition of earlier migrations to the United States. However, the migration experience of Puerto Ricans to the United States is more complex, as well as one of a kind. Similarities do exist between the migration of Puerto Ricans and that of other groups, however, no other ethnic group has shared the tribulations of the Puerto Rican population. Their experience is different from that of anyone else. When Puerto Ricans migrated to the United States they did it in two major waves. The first waveRead MoreChanging World Politics During World War II Essay916 Words   |  4 PagesChanging World Politics In a political system superintended and galvanized by anarchy and inherited norms, transformations and variations are inevitable. The origin of such system began with the â€Å"Peace of Westphalia,† marking the termination of the 30 years war, and was the prominent beginning of the modern international system of where in which Nation States are of the highest institution. This was the end of the ‘Holy Roman Empire’ (of that wasn’t holy nor Roman) and the incalculable scores ofRead MoreWhat It Means To Be A Citizen1010 Words   |  5 Pages(Ginsberg et al. 9). Part of the reason why political opinions vary so far from person to person is in part due to the amount of political knowledge that each individual has. A person who stays informed on current political events weekly by reading newspaper articles will be able to understand our current government structure better than someone who hears about political information from other people’s opinions. V aluable questions are whether or not American politics are in crisis, how this applies to California—heavily

Mesothelioma Free Essays

Mesothelioma is a malignant neoplasm that develops from the mesothelium tissue (a membrane that covers the internal organs present in the body).   It occurs very rarely and is more frequently caused by inhaling asbestos dust.   The incidence of the disease is slowly on the rise. We will write a custom essay sample on Mesothelioma or any similar topic only for you Order Now    In the US, about 2000 new cases are reported every year.   About 70 to 80% of all cases with mesothelioma report exposure to asbestos (NCI, 2002).   Mesothelioma can develop in various sites of the body including the pleura (membranes that covers the lungs), peritoneum (membrane that covers the abdominal cavity), tunica vaginalis testis (membrane that covers the male internal reproductive organs) and tunica serosa uteri (membrane that covers the female internal reproductive organs) (NCI, 2002). It is made up of one layer of flat or cuboidal cells that surround a particular organ or an organ set belonging to a particular group (Weitz Luxenberg, 2006).   In between these membranes a fluid is present that permits some amount of movement during physiologic functioning.   When the asbestos is inhaled, it gets deposited into parenchyma of the lungs from where it enters the immediate membrane that covers the lungs.   It may be carried soon to the other membrane of the lung.   The tumor usually begins as discrete plaques known as ‘malignant mesothelial plaques’ (Weitz Luxenberg, 2006). These discrete masses soon combine to form a large sheet like lesion that spreads.   The exact process by which mesothelioma occurs is not understood clearly, however, it seems that chronic irritation of the membrane plays a very important role (Weitz Luxenberg, 2006).   The chromosomes present in the cell are distorted (Tan, 2007).   One of the most frequent changes in the malignant cell was the loss of a copy of Chromosome 22. The chromosomal picture of the cell seems to be very complex (complex karyotype) and is rearranged (Tan, 2007).   Sometimes, the chromosome arms of 1p, 3p, 9p and 6q may also get structurally rearranged.   This may be brought about by close contact between the chromosomes or the structural proteins with the asbestos particles (Weitz Luxenberg, 2006). The asbestos may get deposited in the peritoneum either through the lymphatic system or the due ingestion of the sputum from the lungs (Weitz Luxenberg, 2006).   The long thin fibers of asbestos are more dangerous than the feathery fibers as they more easily cause cancer.   Once the fibers get deposited in the pleura, the cancer development process actually begins.   In experimental rats, it has been observed that when the pleura or the peritoneum are invaded by the asbestos particles, macrophages and the other cells of the body’s defense mechanism accumulate (Weitz Luxenberg, 2006). As the disease progresses, the macrophages and immune cells continue to invade the lesion.   Slowly the cells get transformed into malignancy.   Studies have demonstrated that the asbestos particles may directly (through physical interaction) and indirectly (through accumulation of macrophages) bring about malignant transformation of the epithelium cells.   Indirectly, the macrophages begin to function abnormally.   They phagocyte the asbestos particles and release higher amounts of hydroxyl radicals. They may stimulate the cancer process by affecting the DNA present in the cell.   Several other substances are released from the macrophages such as mitogens, growth factors, etc, which may bring about chronic irritation.   They also alter entry of certain substances into the cell (by affecting the membrane) and reducing the effect of antioxidant action within the cells.   Asbestos is also known to suppress the action of the body’s defense mechanism by overcoming the action of the lymphocytes (Weitz Luxenberg, 2006). Several structural and functional features have been observed in the cells affected with mesothelioma (which have asbestos particles within the cells): – 1.the suppressor genes against cancers present in the cells may get inactivated when the asbestos fibers enters the cells 2.other cancer-stimulating agents may get activated and affect the cell 3. the DNA of the cell gets altered due to the incorporation of a foreign DNA which encourages cancer formation 4. the DNA repair enzymes may get stimulated and frequently result in a faulty method of repair 5.the cell terminal processes may become abnormal resulting in immortality 6.the DNA sequence may be added at the ends of the cell which makes the cells immortal and results in abnormal functioning (Weitz Luxenberg, 2006) References: NCI. Mesothelioma: Questions and Answers. 2002. NCI. 5 Apr. 2007 http://www.cancer.gov/cancertopics/factsheet/Sites-Types/mesothelioma Tan W.W. â€Å"Mesothelioma.† 2007. E-Medicine. 5 Apr. 2007 http://www.emedicine.com/med/topic1457.htm Weitz Luxenberg. â€Å"The Pathophysiology of Mesothelioma.† 2006. Weitz Luxenberg Inc. 5 Apr. 2007 http://www.weitzlux.com/mesothelioma/Pathophysiology_403723.html How to cite Mesothelioma, Essay examples

Withdholding and Withdrawing Treatment Essay Example For Students

Withdholding and Withdrawing Treatment Essay The majority Of Americans do not have an advanced directive in place. An advanced directive is a written expression of a persons wishes about medical care, especially are during a terminal or critical illness (Butts Rich, 2013, p. 255). Advanced directives can be self-written instructions or prepared by someone else as instructed by the patient. These will become instructions about their future healthcare for other to follow. Some of the issues that need to be addressed in these advanced directives include specific treatments to be refused or desired; the time the directive needs to take effect; specific hospitals and physicians to be used; what lawyer, it any, should be consulted; and any other consultations, such as family or a religious figure (Butts Rich, 2013, p. 255). These advanced receives will be utilized it the patient loses their decision-making capacity and has been rendered incompetent due to their symptoms. The problem arises when the patient does not have this advanced directive. When the patient can no longer make competent decisions, the family might experience difficulty in trying to determine a progressive right course of action. When a patient loses their autonomous decision-making capacity, the decision making falls to a surrogate. A surrogate decision marker is an individual, usually a family member, who acts on behalf of the patient to make decisions about the patients treatment options Butts Rich, 2013, p. 257). Decisions about treatment options can be complex. The surrogate, in absence Of an advanced directive, must consult the attending physician, other family members, and other healthcare providers in order to make the best decision for the patient. Fortunately for surrogates there are ethical principles that can govern their decisions. One of them in particular can be Of comfort to the surrogate. Withholding and Withdrawing treatment from a terminally ill or permanently unconscious patient allows a natural dying process to take its course. It does not constitute killing or assisted suicide (Butts Rich, 013, p. 2571 Medical futility can influence the decision to withhold or withdraw treatment. Medical futility is an unacceptably low chance of achieving a therapeutic benefit for the patient (Butts Rich, 2013, p. 259). Healthcare professionals have accepted and ethically justified withholding and withdrawing treatments deemed futile or extraordinary. Most Other people have also accepted this concept. However, it is not universally accepted. In the 1995 case Of Giggling u. Massachusetts General Hospital, the family Of the patient wanted the attending physician to order CPRM to be provided to the dying patient. The patient, Ms. Giggling, was comatose and dying With multiple organ-system failure. The court supported the physicians claim that CPRM was medically futile (Butts Rich, 2013, p. 261). A permanent vegetative state (PAS) is a state in which a person with severe brain damage has enough autonomic function to survive with constant medical intervention but does not exhibit any awareness or higher brain function (Butts Rich, 2013, p. 52). PAS has played a major role in court cases related to withholding and withdrawing treatment. The case 1976 of Karen Ann Quintal was the first landmark case involving withholding and withdrawing treatment. In 1975, Karen was at a party, mixed alcohol with Valid, lapsed into a coma, and placed on a ventilator. Her parents sued to have her removed from the ventilator. They kept getting denied by the courts. Finally af ter many legal battles, the Nevus Jersey Supreme Court granted her parents the right to remove her from a ventilator. Previously, physicians would not remove her from a ventilator because they could not establish brain death, Once Karen was taken off the ventilator, she continued to breathe on her own for ten years (The big sleep, ND. )_ Because of this case, the definition of and criteria for PAS as established. It also set precedence for parents to have the right to choose withholding and Withdrawing treatment for their child. It also aided in the creation and implementation of the advanced directive. .u5bc4727eb145e7dfe9443e5748d64d56 , .u5bc4727eb145e7dfe9443e5748d64d56 .postImageUrl , .u5bc4727eb145e7dfe9443e5748d64d56 .centered-text-area { min-height: 80px; position: relative; } .u5bc4727eb145e7dfe9443e5748d64d56 , .u5bc4727eb145e7dfe9443e5748d64d56:hover , .u5bc4727eb145e7dfe9443e5748d64d56:visited , .u5bc4727eb145e7dfe9443e5748d64d56:active { border:0!important; } .u5bc4727eb145e7dfe9443e5748d64d56 .clearfix:after { content: ""; display: table; clear: both; } .u5bc4727eb145e7dfe9443e5748d64d56 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u5bc4727eb145e7dfe9443e5748d64d56:active , .u5bc4727eb145e7dfe9443e5748d64d56:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u5bc4727eb145e7dfe9443e5748d64d56 .centered-text-area { width: 100%; position: relative ; } .u5bc4727eb145e7dfe9443e5748d64d56 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u5bc4727eb145e7dfe9443e5748d64d56 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u5bc4727eb145e7dfe9443e5748d64d56 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u5bc4727eb145e7dfe9443e5748d64d56:hover .ctaButton { background-color: #34495E!important; } .u5bc4727eb145e7dfe9443e5748d64d56 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u5bc4727eb145e7dfe9443e5748d64d56 .u5bc4727eb145e7dfe9443e5748d64d56-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u5bc4727eb145e7dfe9443e5748d64d56:after { content: ""; display: block; clear: both; } READ: Drawing on Previous Examples of Major Sporting Events EssayThe 1990 case of Nancy Curran also dealt With the issue Of parents trying to Withhold and Withdraw treatment for their child who was in a PAS. In 1983, Nancy was in an automobile accident and sustained injuries that led to complete loss Of consciousness with significant oxygen deprivation and then to a PAS with continuous artificial nutrition and hydration. After almost eight years of litigation, the Supreme Court f Missouri finally granted the wishes of her parents for the discontinuance of her feeding tube. She died three days after the courts decision (The case of, n. D. ), Because of this case, conditions for withholding and withdrawing treatment were established. The 2005 case of Terra Shiva highlighted the issue of surrogate decision-making in regards to withholding and withdrawing treatment. In 1990, Terra was found unresponsive by her husband, Michael. She had suffered an acute cardiac arrest with prolonged cerebral hypoxia, She was diagnosed with a PAS and had a tending tube in place. Her husband wanted the deeding tube removed, but her parents objected. The feeding tube was removed twice and then replaced because of the legal battle between the husband and the parents, By Florida law, the husband, as spouse and guardian, had a legal right to serve as the surrogate decision maker for Terra. Her parents thought otherwise. A total of twenty-one lawsuits and appeals were filed. After the court finally established that there was clear and convincing evidence that Terra had previously stated that she did not want to live in a condition where she would be a burden to anyone else, the court ordered that the feeding tube be removed or a third and final time. Terra died thirteen days after (Hunter, n_d. N Because of this case, substituted judgment became the ethical and legal standard, with guardianship as the focal point regarding decision making for the withholding and withdrawing of treatment. All of these cases highlight the importance of having an advanced directive and the multitude Of legal complications associated with not having one. The main ethical issue regarding the withholding and Withdrawing Of treatment is Who is the appropriate surrogate decision maker for an incompetent person? As demonstrated in the previous legal cases, if there re no documented preferences, then there is a good chance for a legal dispute between the parties involved who think that they have the right to make that decision. The biggest challenge for a surrogate decision maker is for them to be able to make an unbiased substituted decision based on an understanding of what the patients would decide for themselves, and not the values of the surrogate. To assist the surrogate with making the proper decision, physicians should provide all relevant medical information and explain that decisions regarding withholding or withdrawing life-sustaining treatment should be based hat substituted judgment when there is evidence to the patients preferences and values. In making a substituted judgment, surrogate decision makers may consider the patients advance directive, if any; the patients values about life and the way it should be lived; and the patients attitudes towards sickness, suffering, medical procedures, and death. If there is not adequate evidence of the incompetent patients preferences and values, then the decision should be based on the best interests of the patient including what outcome would most likely promote the patients well-being (Opinion 2. 20, n. D. )_ Because Of the Renville of autonomy the physician should almost always accept the surrogates decision for the incompetent patient. However, there are situations that may require either institutional or judicial review and/or intervention in the decision- making process. These include: there is no available family member willing to be the patients surrogate decision maker, there is a dispute among family members and there is no surrogate decision maker designated in an advanced directive, the physician believes that the familys decision is clearly not what the patient would have decided if competent, and the physician believes that the session is not a decision that could reasonably be judged to be in the patients best interests. .u59b49eb29951b8d331ebf068ff22c7e3 , .u59b49eb29951b8d331ebf068ff22c7e3 .postImageUrl , .u59b49eb29951b8d331ebf068ff22c7e3 .centered-text-area { min-height: 80px; position: relative; } .u59b49eb29951b8d331ebf068ff22c7e3 , .u59b49eb29951b8d331ebf068ff22c7e3:hover , .u59b49eb29951b8d331ebf068ff22c7e3:visited , .u59b49eb29951b8d331ebf068ff22c7e3:active { border:0!important; } .u59b49eb29951b8d331ebf068ff22c7e3 .clearfix:after { content: ""; display: table; clear: both; } .u59b49eb29951b8d331ebf068ff22c7e3 { display: block; transition: background-color 250ms; webkit-transition: background-color 250ms; width: 100%; opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #95A5A6; } .u59b49eb29951b8d331ebf068ff22c7e3:active , .u59b49eb29951b8d331ebf068ff22c7e3:hover { opacity: 1; transition: opacity 250ms; webkit-transition: opacity 250ms; background-color: #2C3E50; } .u59b49eb29951b8d331ebf068ff22c7e3 .centered-text-area { width: 100%; position: relative ; } .u59b49eb29951b8d331ebf068ff22c7e3 .ctaText { border-bottom: 0 solid #fff; color: #2980B9; font-size: 16px; font-weight: bold; margin: 0; padding: 0; text-decoration: underline; } .u59b49eb29951b8d331ebf068ff22c7e3 .postTitle { color: #FFFFFF; font-size: 16px; font-weight: 600; margin: 0; padding: 0; width: 100%; } .u59b49eb29951b8d331ebf068ff22c7e3 .ctaButton { background-color: #7F8C8D!important; color: #2980B9; border: none; border-radius: 3px; box-shadow: none; font-size: 14px; font-weight: bold; line-height: 26px; moz-border-radius: 3px; text-align: center; text-decoration: none; text-shadow: none; width: 80px; min-height: 80px; background: url(https://artscolumbia.org/wp-content/plugins/intelly-related-posts/assets/images/simple-arrow.png)no-repeat; position: absolute; right: 0; top: 0; } .u59b49eb29951b8d331ebf068ff22c7e3:hover .ctaButton { background-color: #34495E!important; } .u59b49eb29951b8d331ebf068ff22c7e3 .centered-text { display: table; height: 80px; padding-left : 18px; top: 0; } .u59b49eb29951b8d331ebf068ff22c7e3 .u59b49eb29951b8d331ebf068ff22c7e3-content { display: table-cell; margin: 0; padding: 0; padding-right: 108px; position: relative; vertical-align: middle; width: 100%; } .u59b49eb29951b8d331ebf068ff22c7e3:after { content: ""; display: block; clear: both; } READ: Drawing The Color Line Essay PaperWhen there are disputes among family members or between family and health care providers, the use of ethics committees specifically designed to facilitate sound decision making is recommended before resorting to the courts (Opinion 2. 20, n. D. ), No matter what decision the physician or the surrogate decision maker determines as the best course of action regarding the withholding and withdrawing of treatment, nurses need to give compassionate, excellent care to the patient. The family members need to feel a sense of inference that the nurses will maintain moral sensitivity with a course of right action. In fact, the American Nurses Association (ANA) in their Code of Ethics for Nurses with Interpretive Statements emphasizes that nurses must ethically support the provision of compassionate and dignified end-of-life care as long as nurses do not have the sole intention of ending a persons life (Butts Rich, 2013, p. 268). This course of right action includes the promotion of comfort, the relief of pain, and support of the family when the decision has been made to withhold or withdrawn treatment. The decision to withhold or withdraw treatment is an incredibly complex ethical issue.

Proposal Essay Bullying Inside If the Education System free essay sample

Bulling Inside of the Education System Bulling is an ongoing thing in the education system weather you are a student or a teacher. Bullying involves repeated occurrences. Bullying is not generally considered a random act or a single incident. Rather, a child is repeatedly picked on by another child or is the target of harassment from a whole group of children. It is the repeated nature of bullying that causes anxiety and apprehension in victims, such that the anticipation of bullying becomes as problematic as the bullying itself. Sometimes people act in such away due to the fact they are jealous of the other person or just for fun. When they are picking on a different individual most of the time they have no idea of the damage they are really causing the other person. The type of bulling that occur in the educational system today include but not limited to emotionally, physically, socially, and sexually. We will write a custom essay sample on Proposal Essay Bullying Inside If the Education System or any similar topic specifically for you Do Not WasteYour Time HIRE WRITER Only 13.90 / page The child who bullies on others wants to harm the victim; it is no accident. School bullying has more than likely existed as long as schools themselves. The consequences of such bullying were once limited to name-calling and occasional schoolyard fights. In recent years, however, school bullying has taken a more serious turn; more and more frequently, bullied students are turning to violence as a solution; either through suicide or through deadly acts carried out against their persecutors and other students. These tragedies have led to heightened awareness among parents, children, educators, and law enforcement experts about the harmful short and long term effects of bullying. School bullying can consist of physical violence against a student, but more often involves ridicule and attempts to humiliate the target student in front of others. The victims are often students who are not part of an established social group at school, such as new students or those who suffer from health or learning disabilities. Bullying campaigns can also be waged over relationship issues such as jealousy. Bullying is characterized by a power difference; unfair fights where the child who bullies has some advantage or power over the child who is victimized. Bullying is not the same as â€Å"playing around,† it is about the abuse of power Almost everyone who was bullied on in school has left school and has stated that bulling was the main reason why they dropped out of school and never returned. Bullying can lead to all types of problems like low self-esteem, depression and insecurity that may continue into adulthood. Over 40 percent of kids that been picked on at school has reported to have low self-esteem compared with only 0. 06 percent in non- bullied groups. As we watched the news or read the paper we hear about thinking about committing suicide. 0 percent of them people actually attempted to do so. The Massachusetts legislature enacted one of the toughest anti-bullying laws in the nation on May 3, 2010. Among other measures, the bill required every school district in the state to submit a comprehensive anti-bullying plan by the end of 2010. Sometimes, victims of bullying seek revenge by lashing out at others. Kids that are b ullied take their frustration out on themselves most of the time. They don’t know how to deals with their problems so they often handle the situation by hurting themselves or hurting others. Most kids will not let anyone know if they are being picked on. If your child is a victim of bullying, getting him to talk about it can be difficult. The child may be afraid that if they tell you the bullying will get worse, or they may feel ashamed that this has happened to them. More than likely they are afraid of how u will react to the saturations they are faced with on a day to day base. There are ways to know if your child is being bullied on in school are Asking often to stay home from school (frequent unexplained minor illnesses such as headaches, stomachaches, etc. ; Damaged/missing clothes or belongings; Frequently ‘lost’ lunch or lunch money; Sleeping problems; Bedwetting; Problems in school such as declining school. Performance, depression, lack of enthusiasm for friends or activities and unexpected changes in routine. Some ways to ask a teenage child if they are being picked on are: what’s it like walk to the bus stop or home from school? What’ s it like on the bus ride to and from school? What happens on the playground during recess or before or after school? What happens in hallways at school or during lunchtime? Have any kids in the neighborhood or at school threatened anyone you know? Do some kids you know get emails, instant messages, or test messages that are upsetting, threatening or insulting? Inclusion, Bulling is one the main reason why children are leaving schools. Bulling is causing people to have low self-esteem, depression issues not only as a child but as an adult as well. Children who are bullied are more likely to develop future academic problems and psychological difficulties. I believe the school should offer support groups for the ones getting bullied on and the ones doing the bullying. No one should have to feel like the only way to deal with a situation is to herm themselves of others. Bulling is doing them more harm than good. They need to know that there are different ways to handle a situation like talking about it with that person or someone with higher power. We must step up and help others deal with this issue at hand. There is no reason to let someone get picked on. If you can help prevent the situation do so don’t just sit back and let it happen.

Valentines Day Activities and Craft Ideas for College Students

Valentines Day Activities and Craft Ideas for College Students Love is in the air Valentines day is coming, and you have no idea how to make this day special for you and your significant other? Or even worse: you have a very limited budget for celebration. Dont worry, we have your back. Weve gathered the best ideas for inexpensive activities and also for DIY gifts that say â€Å"I Love You.† Spending Valentines Day with the One You Love If you want to spend Valentine’s day with your beloved one, take a look at some Valentine’s day ideas of activities that will suit this romantic holiday. Besides, these activities won’t cost you much, so they are perfect for college students on a budget who want to arrange a little holiday just for two. Cooking dinner together Cooking dinner together is a perfect way to build trust and intimacy. Pasta, lasagna or a sweet dessert will work the best. Make sure you shop for all ingredients beforehand to avoid crazy crowds in a market. And don’t forget about scented candles for this romantic evening. Picnic Picnics are so romantic! Do you think that you can’t set up a picnic because of the snowy weather outside? Then make a picnic on the floor in your room. A few blankets, cozy pillows and tasty dinner with wine and good music will make this evening magic and sweet. Source: Instagram Movie evening A great way to celebrate Valentine’s day is to watch a movie or even a few of them. You can take your girlfriend or boyfriend to a movie theater or watch films on Netflix. Take a look at our list of the best movies for Valentine’s day: Dirty Dancing (1987) Pretty Woman (1990) Four Weddings and a Funeral (1994) Love, Actually (2003) Easy A (2010) And don’t forget to buy some popcorn! Source: Depositphotos Cozy boardgame evening Another staying-at-home activity will be an excellent option for those who don’t want to spend too much money or go out. Just make sure you choose a game for two players: Sherlock Holmes Consulting Detective Hive 7 Wonders Duel Crusaders: Thy Will be Done A little competition won’t hurt. Special places Do you and your partner have a â€Å"special place?† It’s the perfect time to visit it. Was it a park you met in or even a train station you had your first kiss at? Go and remind yourself of these precious moments. Source: Cunningham Farms Art classes Pottery and painting classes are excellent therapy and relaxation. Moreover, holding hands together while making pottery on a wheel is the sweetest thing ever! Party Okay, a party doesn’t really seem like a romantic activity, but it’s a great way to spend this day with your girlfriend or boyfriend and other couples in a friendly and funny atmosphere. Themed parties can be organized for any holiday. So, if you’re a party person, host a great party for all of your friends. DIY and Crafting Ideas We love DIYs! And do you? No matter what the occasion is, crafting activities are always entertaining and relaxing. You can prepare gifts yourself or make it an excellent activity for the two of you. We have a whole bunch of cute valentines day ideas for him and her. Cards Source: Pinterest Source: LiaGriffith Valentine’s day cards are pretty pricey when you shop for them in pre-holiday time. But you can make them yourself without spending even an hour of your time. You will need some paper or paperboard, printed designs, markers, and glue. A punch A tasty punch will be an excellent choice for a holiday party or a cozy evening for you and your sweetheart. To make your own punch, you will need some juice, soda, fruits, ice cubes, and a big bowl. Source: Look What I Made Source: Pinterest A surprise box Do you have a gift but don’t know how to present it to your beloved one? A surprise box is a perfect way to make even the simplest gift look like a whole festive ceremony. You will need a big box, balloons, helium, confetti, wrapping paper, and glitter. Put glitter into the balloons and fill them with helium. Decorate your box with wrapping paper, put your gift, confetti, and balloons inside the box, and tape it on the top. Ask your girlfriend or boyfriend to open the box, to make balloons float and find a present on the bottom of the box among confetti. Source: Pinterest Homemade candies Candies are the first thing that comes to mind when speaking about the romantic holiday. If you want to surprise your boyfriend or girlfriend, you can make candies yourself. Use bananas, marshmallows, strawberries, and nuts to dip them in melted chocolate. Let them cool in a fridge, and here you have a tasty dessert for your beloved one. Source: KraftRecipes Source: Cool Mom Eats DIY candles Source: Wonderful DIY Melt some wax or candles you have at home, pour it into ice cube forms of heart shapes covered with a thin layer of oil and place a wick in the center. After the wax is hard, you can take your candles and lit them up. Fun and easy! Or follow easy steps from DIY video tutorials. Hope you liked our ideas of Valentine’s crafts for adults and students. Don’t worry if you have to spend Valentine’s day alone, we have some ideas for a perfect day of fun for singles.

FORD BUSINESS REPORT Essay Example | Topics and Well Written Essays - 2500 words

FORD BUSINESS REPORT - Essay Example This paper has outlined some of the threats posed by other competitors, the unpredictable future especially on the issue of cheap fuel. The assessment has been done using the SWOT analysis in comparison with the competitors. By the end of this paper, one will understand the appropriate measures the company can take to deal with the competition, threats, opportunities and the stagnant European market, which has seemingly remained impervious to Ford. FORD is an automobile company based in the US states but operates in other countries where it manufactures various types of vehicles. Apart from owning various kinds of vehicles, the company has also bought some shares in other companies. For instance, Wilkins (2011) reported that Ford currently has a 21% stake in Japan’s Mazda. Additionally, Ford in UK owns 8% of Aston martin and China’s Jiangling offers 49% to the same company. The company has other ventures where it has worked with other companies like in Russia, Thailand and Turkey Away from the ventures and acquisitions, the company has gone various hurdles including the 2008 recession that saw many countries’ economies suffer adversely. It is during this time that fellow competitors like GM and Chrysler suffered greatly and only the US government’s efforts saved them. Having survived the crisis, Ford registered encouraging results and in 21012, the company had a $134 billion revenue and $ 5,665 billion profit (Grant 2012). At this time, the number of employees in this company had hit the 164,000 mark making it one of the best companies in the US. The essence of writing this report is to highlight its current position and offer recommendations on how to deal with its weaknesses and threats. Like in any other business, Ford has a number of competitors who could be a threat to its profitability unless measures are put in place. In the US, the number of companies rivaling Ford in the automobile business is pretty big. Firstly, the

Team Leadership and Management Essay Example | Topics and Well Written Essays - 750 words

Team Leadership and Management - Essay Example 33). The solutions and strategies proposed by the authors are really practical in today's multinational organizations. Different tasks make a degree of different contributions to the team's various functions in production, support, and well-being. Although technological changes are usually aimed at modifying the team's production function, they almost always have profound effects on the team well-being and member support functions as well. The sharing among team members of both access to the hardware portions of the new technology and of the expertise needed to use and understand the new systems may provide brand new range of the distribution of status and power within a team, dimensions that compare quite poorly with the prior status structure. In terms of underlying social-exchange dynamics, the principal rewards and costs concern task achievement or success. In modern multi-national companies the affective or emotional factor of teamwork is important to all relationships. It is le ss so in task-based, personal relationships than in purely social roles. Team-based approach plays a much important role in the development of team relations than it does in organizations in general (Northhouse, 2003). I agree with the authors that teamwork should be flexible and fit with environmental changes. I would add communication as one of the most important elements in teamwork. The major reason Critique: Team LED 501 for past success is open communication policy and the ability to get people to work together as team. A team leader sees themselves having an informative meeting with employees. They should emphasize open door policy and encourage employees to use it. The task of the team leader is to inform team members that they would like to have some formal meetings for brainstorming and troubleshooting purposes and some informal meetings just as an excuse to get together. Virtually, members of a multi-national workforce behave the same way as traditional teams but pay more attention to interpersonal communication and interaction. In a virtual or practical environment, working relationships vary in their empathy or understanding, effectiveness, and power. The results of ineffective communication range from minor embarrassment to critical problems. Minor embarrassment occurs when we show up at a friend's house for a party on the wrong night; a critical problem occurs. As a human resource professional, one of leaders' responsibilities is to develop and improve the communication process in organization. The authors explain how effective teamwork or group effort can enhance the communication process. The authors do not pay attention to problems and conflicts take place in virtual environment. The communication process is rich with imagery and descriptions. Words and other forms of communication are symbols that bring to mind mental images. In fact, communi cations is basically the management of symbols or language. It is through use of these mental images that we communicate and convey relationships and promote understanding that generates the necessary action to accomplish organizational goals and objectives. These ideas might be supported by the Bible saying: "And do not forget to do

Animal Farm Essay Example | Topics and Well Written Essays - 500 words - 1

Animal Farm - Essay Example Manipulation is one of the tactics utilized by Napoleon to rule the farm. He distorts the true events and changes statements and therefore, keeps the other animals in dark to prevent them from knowing the truth and fighting. The alteration in the principles of Animalism serves as a perfect example. According to the initial stand, all animals were to be treated as same but later the pigs write a new statement which reads, â€Å"All animals are equal, but some animals are more equal than others.† (Orwell 1954). This principle is displayed on the farm to explain to the other animals that the pigs enjoyed greater rights and they were not to be questioned on their acts. Thus, they distort the original dream of Animal Farm and opt for providing greater space for the pigs for the continuation of their rule. Napoleon uses his power to prevent the animals from questioning his rule. He trains a force of dogs for the implementation of his laws and he even issues orders for killings those animals that are not loyal to him. The authority and the fear of the dogs is seen in these lines, â€Å"they had come to a time when no one dared speak his mind, when fierce, growling dogs roamed everywhere, and when you had to watch your comrades torn to pieces after confessing to shocking crimes.†(Orwell 1954). The animals were under threat and they feared for their life owing to which they remained passive and faced all the brutalities that were imposed on them. Thus, force is a factor used by Napoleon to keep his hold on the farm. Napoleon tries to keep the animals as busy as he can and prevents them from learning. He does this to ensure the fact that the animals do not get enough time to think of other problems and so that they cannot realize the fact that they are being ruled and mistreated at the hands of the pigs. â€Å"Napoleon had denounced such ideas as contrary to the spirit of Animalism. The truest happiness,

Drug Discovery Processes

Drug Discovery Processes Introduction Chemistry is not merely a science of making observations in order to better understand nature. Chemistry, as the science of matter and its transformation, plays a central role in bridging between physics, material sciences and life sciences. Our science is creative and productive, generating substances and materials of very high value from almost nothing. In view of its significance, chemical synthesis demands the highest level of scientific/technological creativity and insight to explore its limitless possibilities. Chemical synthesis must pursue the goal of practical elegance; it must be logically elegant and at the same time technologically practical. We must manufacture useful compounds in an economical, energy-efficient, resource-preserving, and environmentally benign way(add ref impo-01). To maintain our current standard of living and to improve quality of life, society has come to depend on the products of chemical industry. The last century has been highly productive in this aspect as it emerges in development in pharmaceutical development, water treatment, material science, polymers, agriculture pesticides and fungicides, detergents, petroleum additives and so forth. Pharmaceutical development plays a vital role as various drugs that are developed have helped in the eradication of many infectious diseases. Although there are certain diseases that have still not found any resistance towards drugs but even though a lot of work is still being carried out on it. Research in the field of pharmaceutical has its most important task in the development of new and better drugs and their successful introduction into clinical practice. â€Å"Medicinal chemistry remains a challenging science which provides profound satisfaction to its practitioners. It intrigues those of us who like to solve problems posed by nature. It verges increasingly on biochemistry and on all the physical, genetic and chemical riddles in animal physiology which bear on medicine. Medicinal chemists have a chance to participate in the fundamentals of prevention, therapy and understanding of diseases and thereby to contribute to a healthier and happier life.† ALFRED BURGER 3   Importance of a Drug: A drug is any chemical or biological substance, synthetic or non-synthetic, that when taken into the organism’s body, will in some way after the functions of that organism’s. This broad definition can be made by including such substances as food. However more strict applications of the word prevail in everyday life. In these cases the word â€Å"drug† is usually used to refer specifically to medicine, vitamins, entheogenic sacraments, consciousness expanding or recreational drugs. Many natural substances such as beers, wine, and some mushrooms, blur the line between food and drugs, when ingested they affect the functioning of both mind and body. The word â€Å"drug† is etymologically derived from the Dutch/Low German word â€Å"droog† which means â€Å"dry†, since in the past; most drugs were dried plant parts. Drugs are usually distinguished from endogenous biochemical by being introduced from outside the organism. For example, insulin is a hormone that is synthesized in the body; it is called a hormone when it is synthesized by the pancreas inside the body, but if it is introduced into the body from outside, it is called a drug. The role played by organic chemistry in the pharmaceutical industry continues to be one of the main drivers in the drug discovery process. However, the precise nature of that role is undergoing a visible change, not only because of the new synthetic methods and technologies now available to the synthetic and medicinal chemist, but also in several key areas, particularly in drug metabolism and chemical toxicology, as chemists deal with the ever more rapid turnaround of testing data that influences their day-to-day decisions. Numerous changes are now occurring in the pharmaceutical industry, not just in the way that the industry is perceived, but also in the rapid expansion of biomedical and scientific knowledge, which affects the way science is practiced in the industry. The recent changes that have occurred in scientific advances are due to the new synthetic techniques and new technologies for rational drug design, combinatorial chemistry, automated synthesis, and compound purification and identification. In addition, with the advent of high-throughput screening (HTS), we are now faced with many targets being screened and many hits being evaluated. However, success in this arena still requires skilled medicinal chemists making the correct choices, often with insight gleaned from interactions with computational chemists and structural biologists, about which â€Å"hits† are likely to play out as true â€Å"lead† structures that will meet the plethora of hurdles that any drug candidate must surmount. It is the mission of pharmaceutical research companies to take the path from understanding a disease to bringing a safe and effective new treatment to patients. Scientists work to piece together the basic causes of disease at the level of genes, proteins and cells. Out of this understanding emerge â€Å"targets,† which potential new drugs might be able to affect. Researchers work to validate these targets, discover the right molecule (potential drug) to interact with the target chosen, test the new compound in the lab and clinic for safety and efficacy and gain approval and get the new drug into the hands of doctors and patients. The drug discovery process goes through following sequences for the development of particular drug4. Pre-discovery (Understand the disease) Before any potential new medicine can be discovered, scientists work to understand the disease to be treated as well as possible, and to unravel the underlying cause of the condition. They try to understand how the genes are altered, how that affects the proteins they encode and how those proteins interact with each other in living cells, how those affected cells change the specific tissue they are in and finally how the disease affects the entire patient. This knowledge is the basis for treating the problem. Researchers from government, academia and industry all contribute to this knowledge base. However, even with new tools and insights, this research takes many years of work and, too often, leads to frustrating dead ends. And even if the research is successful, it will take many more years of work to turn this basic understanding of what causes a disease into a new treatment. Target Identification (Choose a molecule to target with a drug) Once they have enough understanding of the underlying cause of a disease pharmaceutical researchers select a â€Å"target† for a potential new medicine. A target is generally a single molecule, such as a gene or protein, which is involved in a particular disease. Even at this early stage in drug discovery it is critical that researchers pick a target that is â€Å"drugable,† i.e., one that can potentially interact with and be affected by a drug molecule. Target Validation (Test the target and confirm its role in the disease) After choosing a potential target, scientists must show that it actually is involved in the disease and can be acted upon by a drug. Target validation is crucial to help scientists avoid research paths that look promising, but ultimately lead to dead ends. Researchers demonstrate that a particular target is relevant to the disease being studied through complicated experiments in both living cells and in animal models of disease. Drug Discovery (Find a promising molecule that could become a drug) Armed with their understanding of the disease, scientists are ready to begin looking for a drug. They search for a molecule, or â€Å"lead compound,† that may act on their target to alter the disease course. If successful over long odds and years of testing, the lead compound can ultimately become a new medicine. There are a few ways to find a lead compound: Nature: Scientists usually have turned to nature for find interesting compounds for fighting against diseases. Bacteria found in soil and mouldy plants both led to important new treatments. Nature still offers many useful substances, but now there are other ways to approach drug discovery. De novo: Thanks to advances in chemistry, scientists can also create molecules from scratch. They can use sophisticated computer modelling to predict what type of molecule may work. High-throughput Screening: This process is the most common way that leads are usually found. Advances in robotics and computational power allow researchers to test hundreds of thousands of compounds against the target to identify any that might be promising. Based on the results, several lead compounds are usually selected for further study. Biotechnology: Scientists can also genetically engineer living systems to produce disease-fighting biological molecules. Early Safety Tests(Perform initial tests on promising compounds) Lead compounds go through a series of tests to provide an early assessment of the safety of the lead compound. Scientists test Absorption, Distribution, Metabolism, Excretion and Toxicological (ADME/Tox) properties, or â€Å"pharmacokinetics,† of each lead. These studies help researchers prioritize lead compounds early in the discovery process. ADME/Tox studies are performed in living cells, in animals via computational models. Lead Optimization(Alter the structure of lead candidates to improve properties) Lead compounds that survive the initial screening are then optimized, or altered to make them more effective and safer. By changing the structure of a compound, scientists can give it different properties. For example, they can make it less likely to interact with other chemical pathways in the body, thus reducing the potential for side effects. Hundreds of different variations or â€Å"analogues† of the initial leads are made and tested. Teams of biologists and chemists work together closely: The biologists test the effects of analogues on biological systems while the chemists take this information to make additional alterations that are then retested by the biologists. The resulting compound is the candidate drug. Even at this early stage, researchers begin to think about how the drug will be made, considering formulation (the recipe for making a drug, including inactive ingredients used to hold it together and allow it to dissolve at the right time), delivery mechanism (the way the drug is taken – by mouth, injection, inhaler) and large-scale manufacturing (how you make the drug in large quantities). Preclinical Testing(Lab and animal testing to determine if the drug is safe enough for human testing) With one or more optimized compounds in hand, researchers turn their attention to testing them extensively to determine if they should move on to testing in humans. Scientists carry out in vitro and in vivo tests. In vitro tests are experiments conducted in the lab, usually carried out in test tubes and beakers (â€Å"vitro† is â€Å"glass† in Latin) and in vivo studies are those in living cell cultures and animal models (â€Å"vivo† is â€Å"life† in Latin). Scientists try to understand how the drug works and what its safety profile looks like. The U.S. Food and Drug Administration (FDA) require extremely thorough testing before the candidate drug can be studied in humans. During this stage researchers also must work out how to make large enough quantities of the drug for clinical trials. Techniques for making a drug in the lab on a small scale do not translate easily to larger production. This is the first scale up. The drug will need to be scaled up eve n more if it is approved for use in the general patient population. At the end of several years of intensive work, the discovery phase concludes. After starting with approximately 5,000 to 10,000 compounds, scientists now have winnowed the group down to between one and five molecules, â€Å"candidate drugs,† which will be studied in clinical trials. The drugs that are being currently used for curing human ailments mainly comprise of several natural products having complex structures. These are derived from terrestrial micro-organisms, plants and animals. The synthetic analogues of the above or other synthetic compounds that are totally non-natural also serve as drugs. A survey of literature reveals that â€Å"HETEROCYCLES† have been increasingly important not only in the field of medicinal world but also in the agriculture. The chemistry of the heterocyclic compounds is as logical as that of aliphatic or aromatic compounds. This study is of great interest both from the theoretical as well as practical stand point. Heterocyclic compounds are the organic substrates that contain a cyclic structure bearing atoms like nitrogen, oxygen or sulfur in addition to carbon atom as the part of their ring. The cyclic part (from Greek kyklos, meaning circle) of heterocycle indicates that at least one ring structure is present in such a compound and the prefix hetero (from Greek heteros, meaning other or different) refers to non-carbon atom in the ring. The cyclic part of the heterocycle indicates that at least one ring structure is cyclic organic compound that incorporate at least one hetero atom in the rings like cyclopropane or benzene. The presence of the heteroatom gives heterocyclic compounds many significant physical and chemical properties that are usually distinct from those of all carbon-ring analogues. These structures may comprise of either simple aromatic rings or non-aromatic ring. The chemistry of heterocyclic compounds is one of the most interesting and intriguing branch of the organic chemistry which is of equal interests for its theoretical implications, for the diversity of its synthetic procedures and for the physiological and industrial significances.1-2 The variety of heterocyclic compounds is enormous, their chemistry is complex and synthesizing them requires great skill. Among large number of heterocycles found in nature nitrogen heterocycles are most abundant than those containing oxygen or sulphur owing to their wide distribution in nucleic acid instance and involvement in almost every physiological process of plants and animals. It is well known that a number of heterocyclic compounds containing nitrogen, oxygen and sulphur exhibit a wide variety of biological activities. The majority of pharmaceutical products that mimic natural products with biological activity are heterocyclic in nature3 and are of great importance to life because their structural subunits exist in many natural products such as vitamins, hormones, antibiotics and pigments.4,5 Besides the vast distribution of heterocycles in natural products, these substrates are also the major components of biological molecules such as DNA and RNA, in the form of pyrimidine and purine bases. The enzymes possess purely protein structures and the coenzymes incorporate non-amino acid moieties, most of them are aromatic nitrogen heterocycles. Porphyrins8-10 are the backbone of many major compounds and some of their derivatives are fundamental to life, such as heme11 derivatives in blood and chlorophyll is essential for photosynthesis. The heme group of the oxygen-carrying protein-hemoglobin and related compounds such as myoglobin; the chlorophyll, which are the light-gathering pigments of green plants and other photosynthetic organisms, and vitamin B12 are all formed from four pyrrole units joined in a larger ring system known as a porphyrin, such as that of chlorophyll a 1.9 and chlorophyll b 1.10. Many vitamins13 like folic acid 1.12, vitamin B5, nicotinic acid 1.13, nicotinamide 1.14, vitamin B6 pyridoxine 1.15, pyridoxal 1.16, and pyridoxamine 1.17 are well known heterocyclic compounds. Psoralen consists of coumarin fused with furan rings, is used in treatment for skin problems and it shows considerable clinical efficacy.14 Cinchona bark15 has been used for several hundred years for the treatment of malaria where quinine 1.21 is the active heterocyclic component. Caffeine (1,3,7-trimethylxanthine) 1.22 obtained commercially from methylation of xanthine with methyl chloride or dimethylsulphate and alkali, is the major stimulant in tea and coffee. Natural products containing heterocyclic compounds such as alkaloids and glycosides have been used since old age, as remedial agents. Febrifagl alkaloid from ancient Chinese drug, Chang Shan, reserpine from Indian rouwopifia, Curen alkaloid from arrow poison, codenine, j-tropine and strychnine are all examples of heterocyclic compounds. Many alkaloids37 contain a pyridine or piperidine ring structure, among them nicotine 1.55, the main alkaloid constituent of tobacco, is based on the five membered pyrrolidine and six membered pyridine structures and piperine 1.56 which is one of the sharp-tasting constituents of white and black pepper and it is obtained from the plant species piper nigrum. The benzimidazole derivatives 1.64-1.68 having antifungal, antibacterial, anti-inflammatory and analgesics properties have been successfully prepared.41 Imidazo[1,2-a]pyridines have attracted much attention since the beginning of the last century. Due to their important biological activity, they have, in recent years, been broadly investigated and utilized in the pharmaceutical industry. They are also used in bioimaging probes and molecular recognition because of their structural characters.1 In addition, the imidazo[1,2 -a]pyridine scaffolds have been found to be the core structure of many natural products and drugs such as zolpidem, alpidem, saripidem, tenatoprazole, olprinone, and DS-1.2,3 (3)Zhuan Fei, Yan-ping Zhu ⇑, Mei-cai Liu, Feng-cheng Jia, An-xin Wu Tetrahedron Letters 54 (2013) 1222–1226 (imidazo-5 in reference folder) Heterocyclic compounds are obtainable by the following methods. a. Isolation from natural sources, i.e. alkaloids, amino acids, indigo dyes etc. b. Degradation of natural products i.e. acridine, furfural, indol, pyridine, quinoline, thiophene etc. c. Synthesis: Synthesis methods for obtaining heterocyclic compounds may be divided into ring closer reactions, addition reaction and replacement reaction. Cyclisation is usually accomplished by elimination of some small molecules such as water or ammonia from chain of suitable length. Heterocyclic compounds have a great applicability as drugs because, a. They have a specific chemical reactivity. b. They resemble essential metabolism and can provide false synthons in biosynthetic process. Aims and objectives: Taking in view the applicability of heterocyclic compounds, we have undertaken the preparation of heterocycles bearing triazole and pyrimidines nucleus. The placements of a wide variety of substituents of these nuclei have been designed in order to evaluate the synthesized products for their pharmacological profile against several strains of bacteria and fungi and tuberculosis. During the course of our research work, looking to the application of heterocyclic compounds, several entities have been designed, generated and characterized using spectral studies. The details are as under. To synthesize several bioactive derivatives of benzo[d]imidazo and its Schiff’s base and dihydro pyrazolothiazoles. To generate triazolo [1,5-a]pyrimidine derivatives. To synthesize imidazo [1,2-a]pyridine by Green Synthesis and develop their Mannich base. To check purity of all synthesized compounds using thin layer chromatography. To characterize these synthesized products for structure elucidation using various spectroscopic techniques like IR, 1H and 13C NMR and mass spectral studies. To grow single crystal of the synthesized compounds and study there X-ray crystallography for establishment of the structure. To evaluate these new synthesized products for better drug potential against different strains of bacteria and fungi.

Impact of Reducing Global U.S. Troop Deployment Essay -- Effect of Iso

Introduction The United States military is the strongest military that the world has ever seen. However if it is to continue to remain a dominant power it must remain in key positions throughout the world. The United States military is used for more than just fighting the nations wars, it is also used as a diplomatic tool, a deterrent, and to assist in stabilizing the world economy. The effects of reducing U.S. troop presence around the world will have repercussions in more aspects than simply military strength. Deterrence Force Projection is the ability of a nation to apply all or some of its elements of national power (political, economic, informational, or military) to rapidly and effectively deploy and sustain forces in and from multiple dispersed locations to respond to crisis, to contribute deterrence, and to enhance regional stability. Using this definition for force projection the United States is going to put itself at risk if it continues to remove troops from strategically placed overseas assignments. In 2003, it was reported 14 different countries hosted more than 1,000 United States troops. Non-invasion deployments are a common method for deterring regional aggression. Since the 1950’s, an average of about 23% of U.S. troops have been stationed abroad and that a large part of American influence is derived from this military presence throughout the world. (Kane, 2006) One of the main aspects of Army doctrine has been forward presence of its troops. The National Security Strategy of Engagement and Enlargement emphasizes worldwide engagement and the enlargement of the community of free market democracies. In order to be successful in this strategy the United States can not move to a isolationist... ...have had for extended periods of time. The democratic world will feel impacts from the United States willingly taking a backseat on the world stage. Works Cited Collins, John M., 1998. Military Geography for Professionals and the Public. Washington, DC: Brassey’s. Ettlinger, Michael and Linden, Michael. â€Å"A Thousand Cuts.† Center for American Progress, September 2010. Arm'ys europe commander hopes to stave off further troop reductions. (2011, Oct 5). Retrieved from: http://www.nationaldefensemagazine.org/blog/Lists/Posts/Post.aspx?List=7c996cd7-cbb4-4018-baf8-8825eada7aa2&ID=537 Kane, Tim. Global U.S. Troop Deployment, 1950-2005. Center for Data Analysis Report #06-02, The Heritage Foundation, 2006. Buhaung, H., & Gleditsch, N. P. (2005, Sep 26). The death of distance. Retrieved from http://www.prio.no/sptrans/-830327507/2004npg003.pdf

Americas Obesity Epidemic

Cheyenne Rogers English IV Senior Paper America’s Obesity Epidemic Obesity is a chronic condition defined by an excess amount of body fat. Within eight years in the United States, the incidence of obesity has nearly doubled. People throughout America are slowly being affected by this national problem of obesity. The obesity epidemic is growing throughout each state in America, but now reasons for this epidemic are becoming clearer to individuals. Everyone wants to know a reason for the obesity epidemic, and now answers are appearing. Many reasons for this epidemic are due to present day generations, as well as American lifestyles.Fast food has not only come to dominate the American landscape, it has become the most visible American export around the globe (Down to Earth). Cheap and convenient food, busy work lives, and social lives, as well as a constant barrage from media sources have over-loaded Americans are all having a detrimental effect on people’s mental and phys ical health (Thompson). Due to busy lifestyles and laziness throughout America, people have found it easier to go through a drive-thru rather than take the time to go home and make a healthier meal for themselves.Weight gain and obesity are caused by consuming more calories than the body needs (â€Å"Obesity in America†). Genetic determinations, such as the way a body expends energy, hormones, which affect the way that calories are processed, and other organ systems in the body can all affect appetite (â€Å"Obesity in America†). Obesity is a disease that takes time to cure, but people will need to have determination to find a cure and also the understanding and knowing the cure will not come fast or easy. Thus, due to all these causes of obesity, America is in an epidemic that needs to be solved sooner than later.A big contributor to the obesity epidemic is the influence of the environment, such as lifestyles people have created. Within the American environments, what a person eats and how active he or she is, is now considered a lifestyle behavior (â€Å"Genetic Obesity†). Lifestyles contribute to obesity, because not only do families share genes, but they also share their lifestyle habits with in another in each household (â€Å"Genetic Obesity†). In any environment, diets from home are followed and original lifestyles can be carried on throughout life and adds to the ongoing obesity problem.Body functions of humans haven’t changed over the past 50-100 years, yet in society there have been an increasing number of people that are obese over the years (â€Å"Obesity†). Obesity over the past 30 years is most likely due to the recent environmental changes (Brehm). The environmental changes caused the obesity rates to increase over the years instead of decrease. The environment needs to change in a positive way in order for people to live in a healthy society. The media is pressuring people into unhealthy eating habits a nd unhealthy lifestyles.People’s exposure to fast food ads have increased compared to 2003 (â€Å"Effective Summary†). McDonald’s web-based marketing starts with children as young as two years old using Ronald. com (â€Å"Effective Summary†). Exposure to fast food restaurants and ads for these restaurants at such a young age is a major contributor to obesity. Kids are being told at a young age that it is okay to eat junk food; not being told that it is unhealthy for them. Advanced technology is also a factor in media expanding their products.Nine restaurant Facebook pages had more than one million fans as of July 2010, and Starbucks boasted more than 11. 3 million fans (â€Å"Effective Summary†). Smart phone apps were available for eight fast food chains, providing another opportunity to reach out to the young consumers anytime and anywhere (â€Å"Effective Summary†). In occurrence to the new technology, everyone has extra access to ads for all the unhealthy foods. The advanced technology has even gotten to the point where you can order food from your device.The media controls America by constantly pressuring people. The media advertising unhealthy foods it does not help to solve the obesity epidemic, and if this continues the epidemic will not be solved. A big reason for American obesity is because of fast food markers, which tend to be very greedy. Eighty-four percent of parents reported to taking their child to a fast food restaurant at least once in the previous week (Effective Summary). Fast food businesses make it easy for parents to supply food for children at low costs.Parents of the elementary school aged children were more likely to order a combo meal or dollar/value menu item for their child than a kid’s meal for the child (Effective Summary). Each meal is getting smaller and less filling for children pushing to get a bigger meal, even more unhealthy. In this case not only are parents feeding their ch ildren unhealthy foods, but over feeding them as well. Health problems are a result of obesity most people do not know about, such as diseases being results in unhealthy eating for a long period of time.Children and adolescents who eat fast food consume more calories, fat, sugar, and sugar sweetened beverages (Effective Summary). Removal of the nutrients from the body causes extra eating of non-nutritional foods, as the body seeks to regulate the actual levels of the nutrients it truly needs. Removing nutrients from the body is neglect towards the body. In order to be a healthy person it is necessary to consume all nutrients needed. A Finnish study showed that for every one kilogram (2. 2 pounds) increase in body weight, increases the risk of death from coronary artery disease by one percent (â€Å"Obesity†).Obesity is a risk for chronic disease, diabetes, high blood pressure, and some forms of cancer (â€Å"Genetic Obesity†). Continuing to eat junk food is increasing chances of death, which is no joking matter. Most importantly, people should come to realization how serious and controlling obesity can really be. The effects of obesity are not only being physical fitness, but psychological as well. Losing weight and keeping it off can come more of a challenge to some than it does to others (T. J. Clark). This is caused by physical and psychological challenges.Many people continue to ridicule, mock, and even abuse the obese (The Effect of Obesity). People trying to lose weight are extremely vulnerable and are already currently struggling. Therefore, they need others support, not discouraging attitudes. Obese individuals trying to better themselves need support, especially when others find it necessary to constantly degrade the obese on a daily basis. Obese people may have fewer social and romantic relationships compared to the non-obese (Tree). Given that, low self-esteem is common among the severely obese as it is (The Effect of Obesity).Obesity causes much insecurity that people have a difficult time overcoming. A main effect of obesity is people not being pleased with themselves in any way, and no one should feel uncomfortable in their own skin. If the obesity epidemic continues, America will be an unhealthy world to live in, literally. Scientists project that by the year 2015 the number of overweight people in the world will tip to 2. 3 billion with more than 700 million people being obese (Green Life). The predictions have been made and at the rate America is going, these will be the obesity rates in three short years.Since 1995 diabetes rates have doubles in eight states within the United States (F as in Fat: How Obesity Threaten America’s Future 2011). Twenty years ago, no state had an obesity rate over 15 percent, but in today’s world there are two out of three states have obesity rates that are over 25 percent (F as in Fat: How Obesity Threaten America’s Future 2011). Thirty-eight states have hi gh obesity rates, and the rates don’t just stop there†¦ they keep increasing. Our future as Americans is a fat society. As a citizen, everyone should be concerned in helping to solve the ongoing problem, not only to better ourselves but to better our country!This problem can be controlled with motivation to work out and exercise, dedication to better themselves, and cooperation to stop the obesity epidemic from growing, to better each individuals body in America. To start, time reduced from watching the television and in other similar sedentary behaviors (A Vision for the Future: The Obesity Epidemic). Two of the largest fast food advertisers to children have joined the Children’s Food and Beverage Advertising Initiative, CFBAI, pledging to advertise only â€Å"better for you† choices to all children (Effective Summary).Plans to solve this problem are starting to be formed; and people just need to react in a productive way and help out. Other ways to help s olve the problem are to ensure that schools provide healthful food and beverages on school campuses (A Vision for the Future: The Obesity Epidemic). As the President of the International Association for the Study of Obesity, Phillip James, states â€Å"to change the food environment by requiring the companies label on soft drinks or fast food so that people are well informed, this is another way of helping reduce obesity† (Obesity Prevention Needs Change in Living Environment).Actions are taking place now, and soon America will have this problem solved with the help of the citizens from all over. America’s obesity epidemic has been an ongoing problem for the past 20 years. There has been questioning on what to do, how to fix the increasing epidemic, and how to react†¦ but now, the answers are clearly coming out. With support from others, obesity will become one step closer to an epidemic being reduced. Given there are a lot obstacle to go through to stay healthy t here are a lot of easy ways to do it as well. The media is always a pressure, but just think†¦ save a life by not having any health issues throughout life.Avoid the effects of being obese and insecure. And take a step forward and become a part of help our future generations NOT be obese. Now, with the cooperation of fast food companies, you can still get food quickly in the drive through just choose the healthier entree. American citizens created this problem and American citizens will get America a solution as well! Works Cited â€Å"A Vision for the Future: The Obesity Epidemic. † Vision. Vision. org. , 31 Jul 2008. Web. 2 Mar 2012. Brehm, Bonnie, and David D. â€Å"Impact of the Enviroment. † EndoText. EndoText Inc. , 24 Nov 2010. Web. Mar 2012. . â€Å"Executive Summary . † Fast Food f. a. c. t. s.. Rudd Center. Web. 1 Mar 2012. â€Å"F as in Fat: How Obesity Threatens America's Future 2011. † Trust for Americas Health . 2012 Trust for America's Health, Jul 2011. Web. 2 Mar 2012. T. J. Clark. â€Å"Genetic Obesity . † T. J. Clark & Company, 2008. Web. 1 Mar 2012. â€Å"Green Life. † Obesity and the Enviroment . Green Life, 06 Mar 2011. Web. 2 Mar 2012. â€Å"Obesity . † Medicine Net. MedicineNet, Inc, 2012. Web. 2 Mar 2012. † Obesity in America. † Down to Earth . Down to Earth ALL VEGETARIAN Organic & Natural, 16 Sep 2011. Web. 2 Mar 2012. Obesity Prevention Needs Change in Living Environment: Experts. † The Star: Online. Star Publications, 16 Jul 2010. Web. 2 Mar 2012. â€Å"Obesity Prevention Needs Change in Living Environment: experts. † English News. 2012 Xinhua, english. news. cn. , 16 Jul 2010. Web. 1 Mar 2012. â€Å"The Effect of Obesity . † Tree. com, Inc. , 02 Jun 2010. Web. 2 Mar 2012. Thompson, Dennis . â€Å"Too Much Work, Food, Media May Be Hurting Health. † News Health . U. S. News & World Report LP, 06 Jun 2011. Web. 2 Mar 2012. â€Å"Understanding Obesity . † Obesity In America . 2012 Copyright – Obesity in America, 2004.

Dantes Inferno Summarize the story and explain the different Cantos.

Dantes Inferno Summarize the story and explain the different Cantos. Dante's InfernoIn Dante's Inferno, Hell is described in vivid detail in the eyes of Dante, the main character and author. Sinners are eternally punished with tortures that fit their sins. This idea of retributive justice and the role of human reason in the form of Virgil are the two main themes in the poem. Canto VIII contains Dis, the capital of Hell and is most representative of these themes.The sinners caught in the 5th circle, Styx, are the Wrathful, ones that purposely harm others physically or emotionally. There are tortured by attacking each other with foul slime and tearing at each other's flesh. Just as they had attacked others in life, they are forever being attacked in Hell. In almost every Canto, a new class of sinners and their punishments are introduced. This retributive justice is the most obvious theme of the poem.During his journey, Dante is guided by Virgil, the symbol of human reason.Dante And Virgil In Hell by William-Adolphe Bougue...When they approach the boatma n Phlegyas, he becomes enraged that they are not sinners, but Virgil's word convinces Phlegyas to take them across, symbolic that human reason can shine through obstacles. However, Dante address the idea of Hell to be too much for the simple human mind to understand, so an angel must open the doors of Dis for them to pass through.Canto VIII is the most important Canto because it proves the power of human reason and delves into the retributive punishment of the sinners. Dis, being the capital of Hell, signifies the end of understanding and the beginning of the eternal torture behind the human mind.

The Id in Macbeth Essays

The Id in Macbeth Essays The Id in Macbeth Paper The Id in Macbeth Paper The id, according to Freud, represented innate desires such as hunger, sex, and anger. In looking at Macbeth one would assume that Lady Macbeth, being power- hungry as she was, would represent this component, however, these traits were evident in Macbeth himself. In Act II Machetes old drives him to kill Duncan and although his desire is shadowed by that of Lady Macbeth, ultimately he kills, demonstrating the part of Macbeth that is his old. As the play progresses Machetes old becomes Increasingly dominant. In act Ill, scene IV, Macbeth declares, We are yet but young In deed, foreshadowing that his most evil of actions are yet to come. The final act captures the essence of Frauds Idea of the old In Machetes statement While I see lives, the gashes do better upon them, meaning that Macbeth was willing to harm any life that was in his way. Masculinity is another symbol for the id throughout this play. Lady Macbeth questions Machetes masculinity several times at one point asking, are you a man? She also uses manhood when convincing Macbeth to kill Duncan. Later, when Macbeth decides to have Banquet killed he uses masculinity to convince the murderers. He says, ay, in the catalogue ye go for men/ As hounds and greyhounds, mongrels, spaniels, curs/Soughs, water-rugs, and deem-wolves are slept/ All by the name of dogs (actual sentences-96). In Machetes utilization of masculinity to convince the men to kill, It Is further supported that emasculation Is a symbol for the old. Since Lady Macbeth uses this method frequently, It Is evident why one would assume she represents the old, when In reality, she does not. Alternatively, Macbeth has recurring hallucinations that represent the decency in him. Is this a dagger which I see before me, he exclaims, hallucinating, the handle toward my hand, this hallucination occurring in act II supports the idea that perhaps Machetes hallucinations are metaphors for his superego. This represents the moral part of humans. It pulls a person to do the right thing, opposing the old. Although many critics disagree with the idea that Macbeth is a good person, these hallucinations show the existence of a superego, meaning he has some morality thin him. After he commits the murder Macbeth says Will all great Neptune ocean wash the blood clean from my hands? (Actual scene). This is another example of Machetes superego being revealed. The final component In Frauds theory Is the Idea of the Ego which Is the part that maintains a balance between the old and the Superego. Naturally, there would need to be some type of mediator between the two as they are polar opposites. Unnaturally Tort Machete Nils ego Is Tautly Ana ones up Dealing ten reason Tort ten destruction he causes. During the dinner in Act Ill Machetes old and Superego come in direct contact with one another and it results in madness. Macbeth has a hallucination of Banquet, a surfacing of his Superego, in the midst of his Ids every increasing power over him. Theoretically, when the Superego and the old conflict, or when the ego fails to maintain balance between the two, it results in anxiety. When told to take his seat, Macbeth, seeing a ghost of Banquet in his chair, replies with, the tables full. This is the first indicator of the internal collision that is about to occur. Machetes anxiety and unease is demonstrated where now his words and fear are uncontrollable. In this direct clash of Superego and d, Shakespeare reveals Machetes weak Ego in its inability to manage the two extremes within him. Ultimately Macbeth is a story about a man who is neither in conflict with his power-hungry wife, or his lack of character, but his inability to balance between two extremes fighting within him. Shakespeare wrote Macbeth about a man who had a flawed Ego and the calamity that occurred as a result.

Company Promotion Policies Research Paper Example | Topics and Well Written Essays - 1500 words

Company Promotion Policies - Research Paper Example Fron this essay it is clear that if we look at the argument from the company’s perspective, they believe that Maria is a good employee; however, she is loud and aggressive at time in her contact with co-workers and supervisors. Moreover, she has had punctuality issues twice in the past and she gives family problems as the causes. She says that her family needed her help and support and it was her duty to do so. With regard to the accent, it was also cleared out that it was not the company was discriminating her accent, although it was a major consideration. However, it was pointed out that Maria speaks very rapidly and because of her accent, it becomes impossible to understand anything she said. The company says that communication is a very important part of that job description and hence, it cannot be overlooked.This study highlights that  we need to first understand discrimination before we can provide any ruling regarding the company’s promotion policy. We can defi ne discrimination as the bias in treatment that exists towards a certain race, color, sex, nationality. Another explanation of discrimination can be the improper treatment based on unjustified factors. Racial discrimination occurs when a member of one racial group is treated favorably as compared to the member of another racial group. Discrimination in the workplace occurs when there is an unjustified hiring, promotion, job assignment, compensation, or termination of the job... We can define discrimination as the bias in treatment that exists towards a certain race, color, sex, nationality. Another explanation of discrimination can be the improper treatment based on unjustified factors. Racial discrimination occurs when a member of one racial group is treated favorably as compared to the member of another racial group. Discrimination in the workplace occurs when there is an unjustified hiring, promotion, job assignment, compensation, or termination of the job (Blank, Dabady, & Citro, 2004). The law that is most widely used by employees against discrimination is the Title VII of the Civil Rights Act of 1964 which states that, â€Å"to fail or refuse to hire or to discharge any individual, or otherwise to discriminate against any individual with respect to his compensation, terms, conditions, or privileges of employment, because of such individual's race, color, religion, sex, or national origin; or (2) to limit, segregate, or classify his employees or appli cants for employment in any way which would deprive or tend to deprive any individual of employment opportunities or otherwise adversely affect his status as an employee, because of such individual's race, color, religion, sex, or national origin† (Garcez, n.d.). The case at hand is that the company promoted another employee based on his evaluation and his aggressiveness for the job and another employee who is in racial minority in the company believes that there has been discrimination based on sex, race, and language ability. There were three major reasons that contributed towards Maria’s retention at her current post: her aggressive and loud behavior with her co-workers and supervisors, issues with punctuality, and her accent, which

Smoking & its Harms Research Paper Example | Topics and Well Written Essays - 1250 words

Smoking & its Harms - Research Paper Example ed smoking in the public areas as escalating pollution problems, mounting diseases and increase in death rate of citizens activated healthcare organizations to raise voice. Fine of $50 was imposed on the law violators (Adams and Malarcher, 2012). The movement brought considerable results as huge majority of the individuals immediately stopped smoking in public areas but after few months; people were back on track again. Violation of law started again and smoking scenario can be seen in the city. The amount is not that paramount though but pollution in the city is rising due to this problem. People do not smoke in public parks, public transport, and bars but on pedestrian trails; smokers are found (Patel, Thomson and Wilson, 2012). The purpose of this paper is to highlight the problem of smoking in NYC. What is the importance and significance of this problem and what measures are essential to eradicate this problem. The movement started in the recent years along with public response is illustrated in this paper. Moreover critical analysis is exemplified for precise understanding about the issue. The creation of law of non smoking in 2003 had strong basis of the death of 50,000 individuals per annum. The 14 miles beaches of the city beside 1700 parks were declared non smoking areas. The City Council of New York passed the law by keeping in view casualties of several individuals. Smoking was banned on pedestrian walk through, bars, shopping malls too. Respiratory infections, lungs cancer, asthma and cardio vascular diseases emerged due to cigarette smokers. Smokers lay negative impact on the society too. People are not able to enjoy on public spots due to smoking and even pessimistic message is taken by the children (Ossad, 2011). The law against smoking free NYC was formulated in 1988 but amendments in it continued for three consecutive times. Lately in 2003, the law was enforced vibrantly into the city. The rise of this critical issue was important because of